Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4

J Med Chem. 1998 Jan 29;41(3):266-70. doi: 10.1021/jm970685m.
No abstract available

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Binding Sites
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Hydroxamic Acids / chemistry*
  • Models, Chemical
  • Molecular Structure
  • Phosphodiesterase Inhibitors / pharmacology*
  • Pyrrolidinones / chemistry*
  • Pyrrolidinones / pharmacology*
  • Rolipram
  • Structure-Activity Relationship
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Hydroxamic Acids
  • Phosphodiesterase Inhibitors
  • Pyrrolidinones
  • Tumor Necrosis Factor-alpha
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Rolipram